de la Rosa Rafael, Leal Manuel, Rubio Amalia, Martinez-Moya Manuel, Delgado Juan, Ruíz-Mateos Ezequiel, Merchante Elena, Sánchez-Quijano Armando, Eduordo Lissen
Department of Internal Medicine, Virgen del Rocio University Hospital, Seville, Spain.
Antivir Ther. 2002 Sep;7(3):159-63.
The objective of the present study was to assess the impact of baseline thymic volume on the CD4 cell repopulation induced by highly active antiretroviral therapy (HAART) in HIV-infected adults. Therefore, 37 previously untreated HIV-1-infected adults were prospectively followed from August 1998 to September 2001. All patients underwent a thorax CT scan at starting HAART to measure thymic volume. The median follow-up time was 189 [87.5-498.5] days. CD4 cell repopulation was considered as an increase > or = 200 cells/mm3 above baseline count. Twenty-one (57%) patients achieved this CD4 repopulation. Baseline thymic volume was the main independent factor associated with CD4 repopulation (P = 0.016); this factor was a positive predictor (adjusted hazard ratio: 1.25 [95% confidence interval 1.1-1.4]). Although, CD4 cell count and non-AIDS diagnosis at baseline were associated with CD4 cell repopulation on the univariate analysis (P = 0.03 and P = 0.02, respectively), no statistical signification was found on the multivariate test. In summary, baseline thymic volume is a predictor of early CD4 cell repopulation in adult HIV-1-infected patients taking HAART.
本研究的目的是评估基线胸腺体积对接受高效抗逆转录病毒治疗（HAART）的HIV感染成人CD4细胞再增殖的影响。因此，对37例先前未接受治疗的HIV-1感染成人从1998年8月至2001年9月进行了前瞻性随访。所有患者在开始HAART时均接受胸部CT扫描以测量胸腺体积。中位随访时间为189[87.5 - 498.5]天。CD4细胞再增殖定义为比基线计数增加≥200个细胞/mm³。21例（57%）患者实现了这种CD4细胞再增殖。基线胸腺体积是与CD4细胞再增殖相关的主要独立因素（P = 0.016）；该因素是一个阳性预测指标（调整后的风险比：1.25[95%置信区间1.1 - 1.4]）。虽然，在单因素分析中基线CD4细胞计数和非艾滋病诊断与CD4细胞再增殖相关（分别为P = 0.03和P = 0.02），但在多因素检验中未发现统计学意义。总之，基线胸腺体积是接受HAART的成人HIV-1感染患者早期CD4细胞再增殖的一个预测指标。
