Michalodimitrakis M, Papadomanolakis A, Stiakakis J, Kanaki K
Department of Forensic Sciences, University of Crete, Heraklion, Greece.
Med Sci Law. 2002 Oct;42(4):313-7. doi: 10.1177/002580240204200406.
Arrhythmogenic right ventricular cardiomyopathy or dysplasia, a heart muscle disease of unknown cause, is anatomically characterized by variable replacement of myocardial muscle with adipose or fibroadipose tissue. It is usually considered a selective disorder whereas concomitant left ventricular involvement has been noted in a few cases. Two cases of the disease with evidence of extensive left ventricular involvement at pathologic examination are described. Hearts from two patients who died suddenly showed extensive biventricular infiltration by fibrofatty tissue in the first case and exclusively in the wall of the left ventricle the localization of the fatty and fibrotic lesions. These findings might suggest that the various localizations of the fibroadipose tissue are rather different expressions of the same disease and it is preferable to be termed 'arrhythmogenic cardiomyopathy' as other studies also indicate.
致心律失常性右心室心肌病或发育异常是一种病因不明的心肌疾病，其解剖学特征是心肌组织被脂肪或纤维脂肪组织不同程度地替代。它通常被认为是一种选择性疾病，不过少数病例中也发现有左心室受累。本文描述了两例经病理检查证实有广泛左心室受累的该疾病病例。第一例中，两名猝死患者的心脏显示双心室均有广泛的纤维脂肪组织浸润；第二例中，脂肪和纤维化病变仅局限于左心室壁。这些发现可能表明，纤维脂肪组织的不同定位是同一疾病的不同表现形式，正如其他研究也表明的那样，最好将其称为“致心律失常性心肌病”。
