Andrassy Richard J
Department of Surgery, University of Texas Medical School at Houston, Pediatric Surgical Oncology, University of Texas M.D. Anderson Cancer Center, 6431 Fannin, MSB 4.020, 77030, USA.
Am J Surg. 2002 Dec;184(6):484-91. doi: 10.1016/s0002-9610(02)01100-5.
The management of children with soft tissue sarcomas has changed and survival has improved markedly during the past three decades. This is, in large part, due to the multi-modal approach to pediatric malignancies; decreasing the need for radical surgical procedures, while improving survival and decreasing morbidity. The management of patients with rhabdomyosarcomas (RMS) and nonrhabdomyosarcomas soft-tissue sarcomas (NRSTS) as well as neurofibromatosis and related tumors is best accomplished in an organized and systematic fashion with the surgeon involved early in the planning, diagnostic, and treatment phases. Cooperative trials for rhabdomyosarcoma, as part of the Intergroup Rhabdomyosarcoma Study, have led to improved survival with less radical surgery. Ongoing trials of the Soft Tissue Sarcoma Group of the Children's Oncology Group are under way. Since these tumors are rare, cooperative trials are essential to answering the remaining questions regarding extent of surgery and adjuvant therapy.
在过去三十年中，软组织肉瘤患儿的治疗方式发生了变化，生存率显著提高。这在很大程度上归功于对儿童恶性肿瘤采用的多模式方法；减少了根治性手术的需求，同时提高了生存率并降低了发病率。横纹肌肉瘤（RMS）、非横纹肌肉瘤软组织肉瘤（NRSTS）以及神经纤维瘤病和相关肿瘤患者的治疗，最好以有组织、系统的方式进行，外科医生应尽早参与规划、诊断和治疗阶段。作为横纹肌肉瘤协作组研究的一部分，横纹肌肉瘤的合作试验已使生存率提高，手术也不那么激进。儿童肿瘤学组软组织肉瘤组正在进行相关试验。由于这些肿瘤较为罕见，合作试验对于解答有关手术范围和辅助治疗的剩余问题至关重要。
