van Batenburg O D, Kerling K E
Int J Pept Protein Res. 1976;8(1):1-2. doi: 10.1111/j.1399-3011.1976.tb02473.x.
In our investigations on the effect of replacement of histidine by homohistidine (1) on the biological activity of some peptide-hormones, relatively large quantities of Boc-homohistidine were required. Homohistidine being difficult to synthesize, it was essential to find an effective way of introducing the Boc-group. In the past, many syntheses of Boc-histidine were reported (2-6), none of which proved to be quite satisfactory. However, by modifying the procedure of Flouret et al. (6) a convenient method resulting in a high yield of Boc-histidine and Boc-homohistidine was found.
在我们关于用高组氨酸（1）取代组氨酸对某些肽类激素生物活性影响的研究中，需要相对大量的Boc-高组氨酸。由于高组氨酸难以合成，找到一种引入Boc基团的有效方法至关重要。过去，已有许多关于Boc-组氨酸合成的报道（2 - 6），但均不尽人意。然而，通过改进弗洛雷等人（6）的方法，发现了一种简便的方法，可高产率地得到Boc-组氨酸和Boc-高组氨酸。
