Hara Amy K
Department of Radiology, Mayo Clinic, 13400 East Shea Blvd., Scottsdale, AZ 85259, USA.
Gastroenterol Clin North Am. 2002 Dec;31(4):1045-60. doi: 10.1016/s0889-8553(02)00060-2.
The development of colorectal cancer screening alternatives that are attractive to patients and effective for screening is critical for reducing this too-common and deadly disease. CTC is an exciting technique that is the only imaging alternative developed since the barium enema for colon screening. In the past few years, many obstacles to clinical implementation of CTC have been eliminated. For example, there is no longer any post-processing time, which was previously as long as 8 to 10 hours, and the interpretation time has been drastically reduced from 4 hours to 15 to 20 minutes. The majority of studies have demonstrated excellent results for detection of lesions > or = 1 cm, with few false positives. This examination will continue to improve with the development of automated (computer) detection programs and automated 3D rendering algorithms. In addition, cathartic bowel preparation, one of the biggest obstacles to patient compliance with colorectal cancer screening, may be eliminated if successful fecal tagging can be developed. The most important issue that remains is its performance in a screening population, and studies are currently underway to answer that important question.
开发对患者有吸引力且筛查有效的结直肠癌筛查替代方法对于减少这种极为常见的致命疾病至关重要。CT结肠成像（CTC）是一项令人兴奋的技术，是自钡灌肠用于结肠筛查以来开发的唯一成像替代方法。在过去几年中，CTC临床应用的许多障碍已被消除。例如，不再有任何后处理时间，以前后处理时间长达8至10小时，并且解读时间已从4小时大幅减少至15至20分钟。大多数研究表明，对于检测直径大于或等于1厘米的病变，结果极佳，假阳性很少。随着自动（计算机）检测程序和自动三维渲染算法的发展，这项检查将不断改进。此外，如果能够成功开发粪便标记物，那么清肠准备这一患者接受结直肠癌筛查的最大障碍之一可能会被消除。仍然存在的最重要问题是其在筛查人群中的表现，目前正在进行研究以回答这个重要问题。
