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灌注大鼠肝脏合成胍基琥珀酸。

The biosynthesis of guanidinosuccinic acid by perfused rat liver.

作者信息

Perez G, Rey A, Schiff E

出版信息

J Clin Invest. 1976 Mar;57(3):807-9. doi: 10.1172/JCI108340.

DOI:10.1172/JCI108340
PMID:1249211
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC436717/
Abstract

The metabolic pathway for the synthesis of guanidinosuccinic acid was studied in the rat. Labeled guanidinosuccinic acid was isolated from the urine of animals given L-[guanidino-14C]arginine intraperitoneally but did not appear in the urine after administration of D,L-[guanidino-14C]canavanine. Radioactive arginine and nonradioactive aspartic acid and arginine were infused in the isolated, perfused rat liver. After 20 min, small amounts of both labeled and unlabeled guanidinosuccinic acid and large amounts of urea were detected in radiochromatograms of the perfusate. These results support the theory that guanidinosuccinic acid is formed in the liver from transamidination of arginine to aspartic acid.

摘要

在大鼠中研究了胍基琥珀酸的合成代谢途径。从腹腔注射L-[胍基-14C]精氨酸的动物尿液中分离出标记的胍基琥珀酸，但在给予D,L-[胍基-14C]刀豆氨酸后，尿液中未出现该物质。将放射性精氨酸和非放射性天冬氨酸及精氨酸注入离体灌注的大鼠肝脏。20分钟后，在灌注液的放射色谱图中检测到少量标记和未标记的胍基琥珀酸以及大量尿素。这些结果支持了胍基琥珀酸是在肝脏中由精氨酸向天冬氨酸转脒基作用形成的理论。

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本文引用的文献

1
Metabolic control of creatine biosynthesis. I. Effect of dietary creatine.肌酸生物合成的代谢调控。I. 膳食肌酸的作用。
J Biol Chem. 1960 Aug;235:2357-61.
2
Guanidinosuccinic acid in renal failure, experimental azotemia and inborn errors of the urea cycle.肾衰竭、实验性氮质血症及尿素循环先天性代谢异常中的胍基琥珀酸
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Evidence that guanidines and some related compounds cause haemolysis in chronic uraemia.胍类及一些相关化合物在慢性尿毒症中导致溶血的证据。
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Transketolase activity in uremia.尿毒症中的转酮醇酶活性。
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Guanidinosuccinic acid in uremia.尿毒症中的胍基琥珀酸。
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7
Cleavage of canavaninosuccinic acid by human liver to form guanidinosuccinic acid, a substance found in the urine of uremic patients.人肝脏将犬尿氨酸琥珀酸裂解形成胍基琥珀酸，一种在尿毒症患者尿液中发现的物质。
Clin Chem. 1969 May;15(5):397-418.
8
The colorimetric determination of mono- and disubstituted guanidines.
Anal Biochem. 1973 Aug;54(2):545-53. doi: 10.1016/0003-2697(73)90386-2.

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