Saunders J C, Hirsch K A
J Comp Physiol Psychol. 1976 Feb;90(2):212-20. doi: 10.1037/h0077198.
Groups of mice were briefly exposed to a one-octave band of noise at 14, 18, 28, 38, or 58 days of age. Five days later the groups were divided, and some mice were behaviorally tested for audiogenic seizures by reexposing them to the same sound. The round window cochlear microphonic potential was measured in the remaining animals and compared with that observed in unprimed control subjects. Seizure behavior occurred in all animals primed on Day 18 but rarely for subjects in the other age groups. Cochlear microphonic threshold curves in mice primed on Day 18 showed a 30-dB loss in sensitivity, while all other primed groups showed little change. These data were discussed in terms of the "disuse-supersensitivity" hypothesis previously proposed to account for the physiological effects of priming in mice.
将不同年龄组的小鼠（分别为14、18、28、38或58日龄）短暂暴露于一个倍频程的噪声中。五天后，将这些组进行划分，一些小鼠通过再次暴露于相同声音来进行听源性惊厥的行为测试。在其余动物中测量圆窗耳蜗微音器电位，并与未预先处理的对照动物中观察到的电位进行比较。在第18天进行预处理的所有动物中均出现惊厥行为，但在其他年龄组的动物中很少出现。在第18天进行预处理的小鼠的耳蜗微音器阈值曲线显示敏感性损失30dB，而所有其他预处理组几乎没有变化。根据先前提出的“废用-超敏反应”假说来讨论这些数据，该假说是为了解释小鼠预处理的生理效应。
