Glovsky M M, Braunwald J, Opelz G, Alenty A
J Allergy Clin Immunol. 1976 Feb;57(2):134-40. doi: 10.1016/0091-6749(76)90032-4.
Hypersensitivity to procarbazine associated with urticaria, angioedema, and painful joint swelling was found in a 20-year-old student being treated for Hodgkin's disease. A marked fall in complement component activity occurred simultaneously with the development of symtoms. It is suggested that generation of products of complement component activation could be important in the pathogenesis of hypersensitivity to some drugs.
在一名接受霍奇金病治疗的20岁学生中，发现对丙卡巴肼过敏，伴有荨麻疹、血管性水肿和关节疼痛性肿胀。补体成分活性显著下降与症状出现同时发生。提示补体成分激活产物的产生在某些药物超敏反应的发病机制中可能起重要作用。
