Tabak'ian E A, Kukharchuk V V, Naumov V G, Dzemeshkevich S L, Perov P Iu, Tonevitskiĭ A G, Belenkov Iu N, Shumakov V I
Kardiologiia. 2002;42(6):42-6.
Autoantibodies to the second extracellular loop of a cardiac beta1-adrenoreceptors has been detected in some patients with cardiomyopathies and myocarditides. In animal experiments these autoantibodies have been shown to cause reduction of myocardial contractility.
To estimate prevalence of detection of autoantibodies to beta1-adrenoreceptors in patients with myocarditides and cardiomyopathies.
Forty three patients including 18 with dilated cardiomyopathy (DCM), 14 with ischemic heart disease (IHD), 3 with myocarditides, 1 with alcoholic cardiomyopathy and 7 after cardiac transplantation.
Autoantibodies to beta1-adrenoreceptor were determined in patient's blood serum by direct immunoassay. Synthetic fragment containing 26 amino acids of the beta1-adrenoreceptor second loop was used as antigen.
Ten patients had obviously elevated content of autoantibodies. Three of these patients had IHD, 3 - DCM, 1 was studied 6 moths after myocarditis and 3 - 6-9 years after cardiac transplantation. Tests were repeated with intervals from 6 months to 1 year and levels of autoantibodies remained elevated in all these patients. Detection of antibodies did not depend on the etiology of systolic cardiac failure (IHD, DCM), severity of hemodynamic impairment, presence of disorders of cardiac rhythm or conduction.
在一些心肌病和心肌炎患者中检测到了针对心脏β1 - 肾上腺素能受体第二个细胞外环的自身抗体。在动物实验中，这些自身抗体已被证明会导致心肌收缩力下降。
评估心肌炎和心肌病患者中β1 - 肾上腺素能受体自身抗体的检测率。
43例患者，包括18例扩张型心肌病（DCM）患者、14例缺血性心脏病（IHD）患者、3例心肌炎患者、1例酒精性心肌病患者和7例心脏移植术后患者。
采用直接免疫分析法测定患者血清中β1 - 肾上腺素能受体自身抗体。以包含β1 - 肾上腺素能受体第二环26个氨基酸的合成片段作为抗原。
10例患者自身抗体含量明显升高。其中3例为IHD患者，3例为DCM患者，1例为心肌炎后6个月患者，3例为心脏移植后6 - 9年患者。每隔6个月至1年重复检测，所有这些患者的自身抗体水平均持续升高。抗体检测结果不取决于收缩性心力衰竭的病因（IHD、DCM）、血流动力学损害的严重程度、心律失常或传导障碍的存在情况。
