Preobrazhenskiĭ D V, Sidorenko B A, Stetsenko T M, Kiktev V G
Kardiologiia. 2002;42(5):62-7.
Analysis of epidemiological, cohort and randomized studies of antihypertensive drugs containing reports of development of malignant neoplasms shows that long term use of some antihypertensive drugs while preventing cardiovascular complications has been associated with increased risk of malignancies. Most convincing evidence exists for association between the use of diuretics and renal cancer. Association between the use of reserpine and breast cancer in women, between atenolol and some types of cancer in elderly men also can not be ruled out. There is no proof of existence of either negative or positive correlation between malignant neoplasia and long-term use of calcium antagonists, angiotensin converting enzyme inhibitors or angiotensin receptor blockers.
对包含恶性肿瘤发生报告的抗高血压药物的流行病学、队列研究和随机研究分析表明，一些抗高血压药物在预防心血管并发症的同时长期使用与恶性肿瘤风险增加有关。关于利尿剂使用与肾癌之间的关联存在最有说服力的证据。女性使用利血平与乳腺癌之间、老年男性使用阿替洛尔与某些类型癌症之间的关联也不能排除。没有证据证明恶性肿瘤与长期使用钙拮抗剂、血管紧张素转换酶抑制剂或血管紧张素受体阻滞剂之间存在负相关或正相关。
