Kaliuzhin V V, Tepliakov A T, Solovtsov M A
Kardiologiia. 2002;42(3):9-11.
Effects of 12-month therapy with a beta1-adrenoblocker atenolol on the process of late postinfarction remodeling of the heart and parameters of intracardiac hemodynamics were assessed in an open noncomparative study on 55 survivors of macrofocal myocardial infarction. Therapy with atenolol was associated with: (1) reduction of myocardial hypertrophy in patients with increased left ventricular myocardial mass without effect on its volume, cavity geometry and global systolic function; (2) normalization of initially 'hypertrophic' type of transmitral blood flow. Affecting mainly the demand component of the myocardial oxygen supply/demand ratio atenolol promoted inclusion of hibernating cardiomyocytes into active contraction.
在一项针对55名大面积心肌梗死幸存者的开放性非对照研究中，评估了β1肾上腺素能阻滞剂阿替洛尔12个月治疗对心肌梗死后心脏晚期重塑过程及心内血流动力学参数的影响。阿替洛尔治疗与以下情况相关：（1）左心室心肌质量增加的患者心肌肥厚减轻，但其容积、腔室几何形状和整体收缩功能无影响；（2）使最初“肥厚型”的二尖瓣血流恢复正常。阿替洛尔主要影响心肌氧供/需氧比的需求部分，促进冬眠心肌细胞纳入主动收缩。
