Thong Bernard Yu-Hor, Venketasubramanian N
Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore.
Rheumatol Int. 2002 Nov;22(6):256-8. doi: 10.1007/s00296-002-0240-9. Epub 2002 Sep 5.
Primary Sjögren's syndrome (SS) with central nervous system involvement and antiphospholipid syndrome have been reported to mimic multiple sclerosis (MS). SS has also been found in patients diagnosed with definite MS.
A Chinese lady developed multiple relapsing neurological events involving the brain and spinal cord from the age of 40 years. Magnetic resonance imaging of the brain and spinal cord during acute relapses showed increased T2 signals and spinal cord edema. She later developed positive anti-nuclear antibody and anti-Ro autoantibody followed by sicca symptoms, confirming the diagnosis of SS. She died from aspiration pneumonia following pseudobulbar palsy shortly after SS was diagnosed.
Patients with MS-like disease and autoantibodies should be carefully evaluated for other systemic autoimmune diseases as the treatment and prognosis differ from MS. In particular, sicca symptoms should be sought as they often go unnoticed by patients. This is especially important in Orientals in whom MS is relatively uncommon.
据报道，伴有中枢神经系统受累的原发性干燥综合征（SS）和抗磷脂综合征可模仿多发性硬化症（MS）。在确诊为明确MS的患者中也发现了SS。
一名中国女性从40岁起出现多次累及脑和脊髓的复发性神经事件。急性复发期间脑和脊髓的磁共振成像显示T2信号增强和脊髓水肿。她后来出现抗核抗体和抗Ro自身抗体阳性，随后出现干燥症状，确诊为SS。在确诊SS后不久，她因假性延髓麻痹并发吸入性肺炎死亡。
患有类似MS疾病且有自身抗体的患者应仔细评估是否患有其他系统性自身免疫性疾病，因为其治疗和预后与MS不同。特别是应寻找干燥症状，因为患者往往未注意到这些症状。这在MS相对不常见的东方人中尤为重要。
