Newton Alexandra C
Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093-0640, USA.
Biochem J. 2003 Mar 1;370(Pt 2):361-71. doi: 10.1042/BJ20021626.
Phosphorylation plays a central role in regulating the activation and signalling lifetime of protein kinases A, B (also known as Akt) and C. These kinases share three conserved phosphorylation motifs: the activation loop segment, the turn motif and the hydrophobic motif. This review focuses on how phosphorylation at each of these sites regulates the maturation, signalling and down-regulation of PKC as a paradigm for how these sites control the function of the ABC kinases.
磷酸化在调节蛋白激酶A、B(也称为Akt)和C的激活及信号转导寿命方面发挥着核心作用。这些激酶共有三个保守的磷酸化基序:激活环片段、转角基序和疏水基序。本综述重点关注这些位点的磷酸化如何调节蛋白激酶C(PKC)的成熟、信号转导及下调,以此作为这些位点如何控制ABC激酶功能的范例。