Xiao Shouzhong, Guo Xingming, Sun Xiaobo, Xiao Zifu
Biomedical Engineering Department, Chongqing University, Chongqing 400044, China.
Biomed Eng Online. 2002 Dec 6;1:6. doi: 10.1186/1475-925x-1-6.
Although a very close relationship between the amplitude of the first heart sound (S1) and the cardiac contractility have been proven by previous studies, the absolute value of S1 can not be applied for evaluating cardiac contractility. However, we were able to devise some indicators with relative values for evaluating cardiac function.
Tests were carried out on a varied group of volunteers. Four indicators were devised: (1) the increase of the amplitude of the first heart sound after accomplishing different exercise workloads, with respect to the amplitude of the first heart sound (S1)recorded at rest was defined as cardiac contractility change trend (CCCT). When the subjects completed the entire designed exercise workload (7000 J), the resulting CCCT was defined as CCCT(1); when only 1/4 of the designed exercise workload was completed, the result was defined as CCCT(1/4). (2) The ratio of S1 amplitude to S2 amplitude (S1/S2). (3) The ratio of S1 amplitude at tricuspid valve auscultation area to that at mitral auscultation area T1/M1 (4) the ratio of diastolic to systolic duration (D/S). Data were expressed as mean +/- SD.
CCCT(1/4) was 6.36 +/- 3.01 (n = 67), CCCT(1) was 10.36 +/- 4.2 (n = 33), S1/S2 was 1.89 +/- 0.94 (n = 140), T1/M1 was 1.44 +/- 0.99 (n = 144), and D/S was 1.68 +/- 0.27 (n = 172).
Using indicators CCCT(1/4) and CCCT(1) may be beneficial for evaluating cardiac contractility and cardiac reserve mobilization level, S1/S2 for considering the factor for hypotension, T1/M1 for evaluating the right heart load, and D/S for evaluating diastolic cardiac blood perfusion time.
尽管先前的研究已证实第一心音(S1)的振幅与心脏收缩力之间存在非常密切的关系,但S1的绝对值不能用于评估心脏收缩力。然而,我们能够设计出一些具有相对值的指标来评估心脏功能。
对不同组别的志愿者进行测试。设计了四个指标:(1)完成不同运动负荷后第一心音振幅的增加,相对于静息时记录的第一心音(S1)振幅定义为心脏收缩力变化趋势(CCCT)。当受试者完成整个设计的运动负荷(7000焦耳)时,得到的CCCT定义为CCCT(1);当仅完成设计运动负荷的1/4时,结果定义为CCCT(1/4)。(2)S1振幅与S2振幅的比值(S1/S2)。(3)三尖瓣听诊区S1振幅与二尖瓣听诊区S1振幅的比值T1/M1(4)舒张期与收缩期持续时间的比值(D/S)。数据以平均值±标准差表示。
CCCT(1/4)为6.36±3.01(n = 67),CCCT(1)为10.36±4.2(n = 33),S1/S2为1.89±0.94(n = 140),T1/M1为1.44±0.99(n = 144),D/S为1.68±0.27(n = 172)。
使用指标CCCT(1/4)和CCCT(1)可能有助于评估心脏收缩力和心脏储备动员水平,S1/S2用于考虑低血压因素,T1/M1用于评估右心负荷,D/S用于评估舒张期心脏血液灌注时间。