Koh Phil Ok, Undie Ashiwel S, Kabbani Nadine, Levenson Robert, Goldman-Rakic Patricia S, Lidow Michael S
Departments of Oral and Craniofacial Biological Sciences, University of Maryland, Baltimore 21201, USA.
Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):313-7. doi: 10.1073/pnas.232693499. Epub 2002 Dec 20.
The delineation of dopamine dysfunction in the mentally ill has been a long-standing quest of biological psychiatry. The present study focuses on a recently recognized group of dopamine receptor-interacting proteins as possible novel sites of dysfunction in schizophrenic and bipolar patients. We demonstrate that the dorsolateral prefrontal cortex in schizophrenia and bipolar cases from the Stanley Foundation Neuropathology Consortium display significantly elevated levels of the D2 dopamine receptor desensitization regulatory protein, neuronal calcium sensor-1. These levels of neuronal calcium sensor-1 were not influenced by age, gender, hemisphere, cause of death, postmortem period, alcohol consumption, or antipsychotic and mood stabilizing medications. The present study supports the hypothesis that schizophrenia and bipolar disorder may be associated with abnormalities in dopamine receptor-interacting proteins.
在精神病患者中描绘多巴胺功能障碍一直是生物精神病学长期以来的追求。本研究聚焦于一组最近被认识的多巴胺受体相互作用蛋白，它们可能是精神分裂症和双相情感障碍患者功能障碍的新位点。我们证明，来自斯坦利基金会神经病理学联盟的精神分裂症和双相情感障碍病例的背外侧前额叶皮质显示出D2多巴胺受体脱敏调节蛋白——神经元钙传感器-1的水平显著升高。神经元钙传感器-1的这些水平不受年龄、性别、脑半球、死因、死后间隔时间、酒精摄入或抗精神病药物及心境稳定剂的影响。本研究支持这样的假说，即精神分裂症和双相情感障碍可能与多巴胺受体相互作用蛋白的异常有关。
