Andrews Daniel M, Scalzo Anthony A, Yokoyama Wayne M, Smyth Mark J, Degli-Esposti Mariapia A
Department of Microbiology, School of Biomedical and Chemical Sciences, The University of Western Australia, Nedlands, Perth, Australia.
Nat Immunol. 2003 Feb;4(2):175-81. doi: 10.1038/ni880. Epub 2002 Dec 23.
Ly49H(+)NK1.1(+) natural killer (NK) cells are essential for the control of murine cytomegalovirus (MCMV) during the acute stage of infection. This cell subset expands at the later stages of infection in an MCMV-specific fashion. Here we demonstrate a critical interaction between Ly49H(+) NK cells and CD8alpha(+) dendritic cells (DCs) whereby the presence of Ly49H(+) NK cells results in maintenance of CD8alpha(+) DCs in the spleen during acute MCMV infection. Reciprocally, CD8alpha(+) DCs are essential for the expansion of Ly49H(+) NK cells by a mechanism involving interleukin 18 (IL-18) and IL-12. This study provides evidence for a functional interrelationship between DCs and NK cells during viral infection and defines some of the critical cytokines.
Ly49H(+)NK1.1(+)自然杀伤（NK）细胞在鼠巨细胞病毒（MCMV）感染急性期对其控制至关重要。该细胞亚群在感染后期以MCMV特异性方式扩增。在此，我们证明了Ly49H(+)NK细胞与CD8α(+)树突状细胞（DCs）之间的关键相互作用，即Ly49H(+)NK细胞的存在导致急性MCMV感染期间脾脏中CD8α(+)DCs的维持。相反，CD8α(+)DCs通过涉及白细胞介素18（IL-18）和IL-12的机制对Ly49H(+)NK细胞的扩增至关重要。本研究为病毒感染期间DCs与NK细胞之间的功能相互关系提供了证据，并确定了一些关键细胞因子。
