Semenchuk Marilyn R
Curr Opin Investig Drugs. 2002 Sep;3(9):1369-72.
Avinza is a once-daily morphine sulfate controlled-release formulation utilizing SODAS (Spheroidal Oral Drug Absorption System) technology developed by Elan and Ligand for the potential treatment of pain [220806], [223862]. This multiparticulate product is designed to provide a rapid onset of action together with a sustained therapeutic effect over 24 h. It is thought that once-daily administration should improve compliance and help eliminate breakthrough pain which is a feature of many twice-daily products, thereby providing better pain management [220806].
阿维扎是一种每日一次的硫酸吗啡控释制剂，采用了由伊兰公司和礼来公司开发的SODAS（球形口服药物吸收系统）技术，用于潜在的疼痛治疗[220806]，[223862]。这种多颗粒产品旨在提供快速起效以及持续24小时的治疗效果。据认为，每日一次给药应能提高依从性，并有助于消除许多每日两次给药产品所具有的突破性疼痛，从而实现更好的疼痛管理[220806]。
