Synthetic metabolites of neurohypophyseal hormones. (Des-9-glycinamide)oxytocin and (des-9-glycinamide, des-8-leucine)oxytocin.

Syntheses and biological properties are reported for two analogs of oxytocin in which the glycinamide and the leucylglycinamide moiety, respectively, have been deleted from the parent hormone. Both [des-9-glycinamide]oxytocin and [des-9-glycinamide,des-8-leucine]oxytocin are weak agonists in the rat uterotonic and antidiuretic assays but possess no detectable rat pressor activity. In addition, [des-9-glycinamide]oxytocin is an inhibitor of the oxytocin-induced vasodepressor response in fowl but is a potent agonist in the hydroosmotic assay of the toad urinary bladder.