Valen Maurice, Ganz Scott D
Impladent Ltd, Holliswood, NY 11423, USA.
J Oral Implantol. 2002;28(4):167-77. doi: 10.1563/1548-1336(2002)028<0167:ASBRGF>2.3.CO;2.
Animal studies were conducted to evaluate the cell response and chemical potentiality of a synthetic bioactive resorbable graft (SBRG) made of nonceramic cluster particulate of low-temperature HA material. The study evaluated bone-bridging of the SBRG particulates in 1-mm wide implant channels of 5 x 8 mm long roughened titanium interface in 6 dogs and compared results to the same implant channels left empty as controls at 6- and 12-week intervals. Resorption rate capacity and cell response were evaluated with an assessment of the chemical characterization of the synthetic nonceramic material next to the titanium implant interfaces. Results of the animal studies were compared with human histologic biopsies of the SBRG for bone quality, density, and bone growth into defect sites concurrent with resorption time of the graft. One human biopsy consisted of a graft mixture of the SBRG and dense bovine-derived HA, compared under the electron microscope, including histology by H and E staining. Part 1 of this paper presents evidence of the predictability and efficacy of the SBRG osteoconductive, particulate chemical potentiality to aid in the regeneration of lost bone anatomy next to titanium implant interfaces. Recent technological innovations in computer hardware and software have given clinicians the tools to determine 3-dimensional quality and density of bone, including anatomical discrepancies, which can aid in the diagnosis and treatment planning for grafting procedures. When teeth are extracted, the surrounding bone and soft tissue are challenged as a result of the natural resorptive process. The diminished structural foundation for prosthetic reconstruction, with or without implants, can be compromised. A synthetic bioactive resorbable graft material having osteoconductive biochemical and biomechanical qualities similar to the host bone provides the means to improve compromised bone topography for ridge preservation, ridge augmentation, or to enhance the bony site for implant placement and subsequent prosthetic rehabilitation. Part two of this paper will demonstrate clinical applications of the SBRG material for purposes of implant placement and prosthetic reconstruction.
进行了动物研究，以评估由低温HA材料的非陶瓷簇颗粒制成的合成生物活性可吸收移植物（SBRG）的细胞反应和化学潜能。该研究评估了6只狗的5×8mm长的粗糙钛界面的1mm宽植入通道中SBRG颗粒的骨桥接情况，并在6周和12周的间隔时间将结果与作为对照的空植入通道进行比较。通过评估钛植入界面旁边合成非陶瓷材料的化学特性来评估吸收速率能力和细胞反应。将动物研究的结果与SBRG的人类组织活检进行比较，以评估骨质量、密度以及骨向缺损部位的生长情况与移植物吸收时间的关系。一份人类活检样本包含SBRG与致密牛源性HA的移植物混合物，在电子显微镜下进行比较，包括苏木精和伊红染色的组织学检查。本文的第一部分展示了SBRG骨传导性、颗粒化学潜能在辅助钛植入界面旁缺失骨结构再生方面的可预测性和有效性的证据。计算机硬件和软件方面的最新技术创新为临床医生提供了确定骨的三维质量和密度的工具，包括解剖差异，这有助于移植手术的诊断和治疗规划。拔牙时，由于自然吸收过程，周围的骨和软组织会受到影响。无论有无植入物，用于假体重建的结构基础减弱都可能受到损害。一种具有与宿主骨相似的骨传导生化和生物力学特性的合成生物活性可吸收移植物材料，为改善受损的骨形态以进行牙槽嵴保存、牙槽嵴增高或增强植入部位的骨量并随后进行假体修复提供了手段。本文的第二部分将展示SBRG材料在植入物放置和假体重建方面的临床应用。
