哒嗪类化合物。第31部分：4,5-二取代-6-苯基-3(2H)-哒嗪酮的合成与抗血小板活性
Pyridazines. Part 31: synthesis and antiplatelet activity of 4,5-disubstituted-6-phenyl-3(2H)-pyridazinones.
作者信息
Sotelo Eddy, Fraiz Nuria, Yáñez Matilde, Laguna Reyes, Cano Ernesto, Raviña Enrique
机构信息
Departamento de Química Orgánica, Laboratorio de Química Farmacéutica, Esapaña.
出版信息
Chem Pharm Bull (Tokyo). 2002 Dec;50(12):1574-7. doi: 10.1248/cpb.50.1574.
PMID:12499593
Abstract
This paper describes the synthesis and the antiplatelet activity of a series of 4,5-disubstituted-6-phenyl-3(2H)-pyridazinones. Some of these compounds show a dose-dependent activity and were found to be more active than their 5-substituted analogues.
摘要
本文描述了一系列4,5-二取代-6-苯基-3(2H)-哒嗪酮的合成及其抗血小板活性。其中一些化合物表现出剂量依赖性活性，并且被发现比它们的5-取代类似物更具活性。
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