一种从反式-communic 酸合成强效癌症化学预防剂 13-氧代-15,16-二降-labda-8(17),11E-二烯-19-酸的新方法。
A new synthesis of a potent cancer chemopreventive agent, 13-oxo-15,16-dinorlabda-8(17),11E-dien-19-oic acid from trans-communic acid.
作者信息
Katoh Takahiro, Tanaka Reiko, Takeo Masatoshi, Nishide Kiyoharu, Node Manabu
机构信息
Kyoto Pharmaceutical University, Yamashina, Japan.
出版信息
Chem Pharm Bull (Tokyo). 2002 Dec;50(12):1625-9. doi: 10.1248/cpb.50.1625.
PMID:12499606
Abstract
The first synthesis of a labdane diterpenoid, (-)-13-oxo-15,16-dinorlabda-8(17),11E-dien-19-oic acid [(-)-1a], isolated from the stem bark of Thuja standishii (GORD.) CARR., from the major component trans-communic acid (3a) is described.
摘要
描述了从日本扁柏（Thuja standishii (GORD.) CARR.）茎皮中分离出的一种半日花烷二萜类化合物（-）-13-氧代-15,16-二降半日花-8(17),11E-二烯-19-酸[（-）-1a]的首次合成，该合成以主要成分反式-communic酸（3a）为原料。
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