[哺乳动物硒蛋白的研究进展]

[Progress in the study of mammalian selenoprotein].

作者信息

Zhang Z X, Yang X G, Xia Y M, Chen X S

机构信息

Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing 100050.

出版信息

Sheng Li Ke Xue Jin Zhan. 1998 Jan;29(1):29-34.

PMID:12501700

Abstract

Selenium is an essential trace element for animals and humans. Selenium exerts its biological function largely through selenoproteins. Up to now nine selenoproteins' cDNAs have been cloned and sequenced, which are cellular glutathione peroxidase (cGPX), extracellular glutathine peroxidase(eGPX), phospholipid hydroperoxidase glutathione peroxidase(PHGPX), gastrointestinal glutathione peroxidase (GPX-GI), type I iodothyronine 5'-deiodinase (ID I), type 2 iodothyronine 5'-deiodinase(ID II), type III iodothyronine 5-deiodinase(ID III), selenoprotein P (Se-P) and selenoprotein W. In all these selenoproteins Se is incorporated into the protein molecule via the selenocysteinyl-tRNA which recognizes the specific UGA codons in mRNA to insert selenocysteine into the primary structure of selenoproteins.

摘要

硒是动物和人类必需的微量元素。硒主要通过硒蛋白发挥其生物学功能。到目前为止，已有9种硒蛋白的cDNA被克隆和测序，它们分别是细胞谷胱甘肽过氧化物酶（cGPX）、细胞外谷胱甘肽过氧化物酶（eGPX）、磷脂氢过氧化物谷胱甘肽过氧化物酶（PHGPX）、胃肠道谷胱甘肽过氧化物酶（GPX-GI）、I型碘甲状腺原氨酸5'-脱碘酶（ID I）、II型碘甲状腺原氨酸5'-脱碘酶（ID II）、III型碘甲状腺原氨酸5-脱碘酶（ID III）、硒蛋白P（Se-P）和硒蛋白W。在所有这些硒蛋白中，硒通过硒代半胱氨酰-tRNA掺入蛋白质分子，该tRNA识别mRNA中的特定UGA密码子，将硒代半胱氨酸插入硒蛋白的一级结构中。