Modulation of cocaine-induced place preferences by alcohol.

Behavioral and physiological evidence suggests that alcohol modulates the effects produced by cocaine. To assess whether such modulation is evident with cocaine's affective properties, the present studies examined the effects of alcohol on cocaine-induced conditioned place preferences (CPP). In Experiment 1, male Sprague-Dawley rats were assigned to one of three groups based on whether they were conditioned with 20 mg/kg cocaine (Group C), 0.5 g/kg alcohol (Group A), or the combination (Group C/A). On the first conditioning trial, animals were injected with the drug(s) or vehicle and placed on one side of a place preference apparatus. On the next day, animals initially injected with drug received vehicle (and vice versa) and placed on the other side of the chamber. This cycle was repeated four times. Animals were then tested for their compartment preference. In Experiment 2, subjects were treated identically except that 1.5 g/kg alcohol was administered. In both experiments, Group C displayed a significant preference for the drug-paired compartment. Group A (in both experiments) showed no conditioned effect. In Experiment 1, Group C/A failed to display a significant preference, spending an amount of time in each compartment that was the numerical average of Groups C and A. In Experiment 2, the cocaine-induced preference was completely abated by 1.5 g/kg alcohol. These results indicate that alcohol produces a dose-dependent modulation of the affective properties of cocaine.