Cocaine, but not alcohol, reinstates cocaine-induced place preferences.

Alcohol has been reported to modulate the reinforcing and aversive properties of cocaine. Given these effects, the present study examined whether this interaction could be extended to cocaine seeking using the conditioned place preference (CPP) procedure. Specifically, 31 drug-naive, male Sprague-Dawley rats were injected every other day (for 8 days) with either 20 mg/kg cocaine or vehicle in an alternating sequence prior to being restricted to a drug or vehicle side of a place preference chamber for 30 min. On Day 9, subjects were given 15-min access to the entire chamber to assess compartment preference. Animals then underwent extinction by pairing both compartments with vehicle for an additional 8 days. Extinction was assessed in the same manner as place conditioning. The animals were then given priming injections of vehicle, 15 mg/kg cocaine, 0.5 or 1.0 g/kg alcohol on the day following the extinction test. Pairing 20 mg/kg cocaine with a specific compartment resulted in a significant place preference. Breaking the relation between the compartment and the drug by pairing both compartments with vehicle extinguished this preference. Interestingly, only 15 mg/kg cocaine was able to reinstate the cocaine-induced place preference, suggesting that the ability to reinstate cocaine seeking may be drug specific.