Housman Tamara Salam, Mellen Beverly G, Rapp Stephen R, Fleischer Alan B, Feldman Steven R
Department of Dermatology, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA.
Cutis. 2002 Dec;70(6):327-32.
Psoriasis patients' acceptance of the vehicles used in topical therapy contributes to adherence to treatment plans and outcomes, but patient preferences for different vehicles have not been assessed. The purpose of this study was to develop a quantitative measure of patient preferences for different vehicles and to assess these preferences. Focus group sessions were conducted of patients with psoriasis to determine patient perceptions of the advantages and disadvantages of different topical psoriasis therapies. This information was used to derive a vehicle preference measure to assess different topical therapies. Twenty patients with psoriasis sampled different topical psoriasis medications, assessed the effects of the vehicles on quality of life (QOL), and completed the preference measure for each vehicle. The focus group sessions resulted in the development of a 7-item preference measure. The validity of the vehicle preference measure was demonstrated by good correlation with patient expectations of effects on QOL and by test-retest reliability. The foam and solution vehicles were preferred over the cream, gel, and ointment vehicles (P < .01). There was no significant difference between preferences for daytime and nighttime application of vehicles. Although validated measures of adherence to topical therapy are not yet available, the results of this study suggest that the characteristics of solution and foam may favor improved adherence to topical therapy.
银屑病患者对局部治疗所用载体的接受程度有助于其坚持治疗方案并取得治疗效果，但尚未对患者对不同载体的偏好进行评估。本研究的目的是开发一种定量方法来衡量患者对不同载体的偏好，并评估这些偏好。对银屑病患者进行了焦点小组讨论，以确定患者对不同局部银屑病治疗方法优缺点的看法。这些信息被用于推导一种载体偏好衡量方法，以评估不同的局部治疗方法。20名银屑病患者试用了不同的局部银屑病药物，评估了载体对生活质量（QOL）的影响，并完成了对每种载体的偏好衡量。焦点小组讨论产生了一种包含7个条目的偏好衡量方法。载体偏好衡量方法的有效性通过与患者对生活质量影响的预期的良好相关性以及重测信度得到了证明。泡沫剂和溶液剂载体比乳膏剂、凝胶剂和软膏剂载体更受青睐（P < .01）。载体在白天和夜间使用的偏好之间没有显著差异。尽管尚未有经过验证的局部治疗依从性衡量方法，但本研究结果表明，溶液剂和泡沫剂的特性可能有利于提高局部治疗的依从性。
