水合氯醛介导的细胞分裂和质子合成抑制作用。

Chloral hydrate mediated inhibition of cell division and of proton synthesis.

作者信息

McMahon D, Göpel G

出版信息

Mol Cell Biochem. 1976 Jan 31;10(1):27-31. doi: 10.1007/BF01731678.

Abstract

Chloral hydrate (along with other anaesthetics and hypnotics) is an inhibitor of cell division. We have shown that chloral hydrate is also an inhibitor of protein synthesis. This inhibition is unlikely to be a result of either of the disruption of cell division or of interference with the function of microtubules. The ability of chloral hydrate to inhibit cell division may result from its ability to inhibit protein synthesis.

摘要

水合氯醛（与其他麻醉剂和催眠药一样）是一种细胞分裂抑制剂。我们已经表明，水合氯醛也是一种蛋白质合成抑制剂。这种抑制不太可能是细胞分裂中断或微管功能干扰的结果。水合氯醛抑制细胞分裂的能力可能源于其抑制蛋白质合成的能力。