FASTIER F N, SPEDEN R N, WAAL H
Br J Pharmacol Chemother. 1957 Jun;12(2):251-6. doi: 10.1111/j.1476-5381.1957.tb00129.x.
Various drugs have been tested for a capacity to prolong the hypnotic effect of chloral hydrate in mice. Amongst the compounds which, when injected subcutaneously in substantial amount shortly before the chloral hydrate (250 mg./kg. intraperitoneally), increased sleeping time significantly were adrenaline, noradrenaline, phenylephrine, methoxamine, 5-hydroxytryptamine (serotonin), histamine, ergotamine, yohimbine, and atropine. The ability of these drugs to prolong chloral hydrate sleeping time could not be related to any common circulatory property, but most of the active drugs are known to lower body temperature under comparable conditions. It was found that mice which have been pre-treated with 5-hydroxytryptamine or adrenaline suffer a much greater fall of body temperature when chloral hydrate is given subsequently than do mice which have been given chloral hydrate alone. It is suggested that some, at least, of the drugs which prolong the effects of hypnotics do so by virtue of a hypothermic action.
已对多种药物延长水合氯醛对小鼠催眠作用的能力进行了测试。在水合氯醛（腹腔注射250毫克/千克）之前不久大量皮下注射时，能显著延长睡眠时间的化合物有肾上腺素、去甲肾上腺素、苯肾上腺素、甲氧明、5-羟色胺（血清素）、组胺、麦角胺、育亨宾和阿托品。这些药物延长水合氯醛睡眠时间的能力与任何常见的循环特性均无关联，但已知大多数活性药物在类似条件下会降低体温。研究发现，预先用5-羟色胺或肾上腺素处理过的小鼠，随后给予水合氯醛时，其体温下降幅度比单独给予水合氯醛的小鼠大得多。有人提出，至少部分延长催眠药作用的药物是通过低温作用来实现的。
