来自准噶尔阿魏的倍半萜类化合物。

Sesquiterpenes from Ferula penninervis.

作者信息

Shikishima Yasuhiro, Takaishi Yoshihisa, Honda Gisho, Ito Michiho, Takeda Yoshio, Tori Motoo, Takaoka Shigeru, Kodzhimatov Olimjon K, Ashurmetov Ozodbek

机构信息

Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan.

出版信息

J Nat Prod. 2002 Dec;65(12):1897-903. doi: 10.1021/np020014d.

DOI:10.1021/np020014d

PMID:12502335

Abstract

The ethyl acetate soluble extract of the dried roots of Ferula penninervis gave 17 new sesquiterpenes [15 of the guaiane-type, ferupennins A-O (1-15), and two of the eudesmane-type, 1alpha-hydroxy-2-oxo-5alpha,7beta,11betaH-eudesm-3-en-6alpha,12-olide (16) and penninervin (17)] and nine known sesquiterpenes. The structures of the new compounds were elucidated on the basis of spectroscopic evidence and X-ray analysis. The absolute configuration of ferupennin A (1) was determined by a modified Mosher method.

摘要

阿魏（Ferula penninervis）干燥根的乙酸乙酯可溶提取物得到了17个新的倍半萜（15个愈创木烷型，即阿魏倍半萜A - O，1 - 15；2个桉叶烷型，即1α - 羟基 - 2 - 氧代 - 5α,7β,11βH - 桉叶 - 3 - 烯 - 6α,12 - 内酯，16；以及阿魏宁，17）和9个已知倍半萜。通过光谱证据和X射线分析阐明了新化合物的结构。阿魏倍半萜A（1）的绝对构型通过改良的莫舍尔方法确定。