Suzuki Kyoko, Okasaka Mamoru, Kashiwada Yoshiki, Takaishi Yoshihisa, Honda Gisho, Ito Michiho, Takeda Yoshio, Kodzhimatov Olimjon K, Ashurmetov Ozodbek, Sekiya Michiko, Ikeshiro Yasumasa
Graduate School of Pharmaceutical Sciences, University of Tokushima, Tokushima, Japan.
J Nat Prod. 2007 Dec;70(12):1915-8. doi: 10.1021/np0703996. Epub 2007 Dec 4.
The ethyl acetate-soluble fraction from a MeOH extract of the roots of Ferula varia gave six new sesquiterpene lactones (1-6) and five known sesquiterpenes (7-11). Their structures were established on the basis of spectroscopic evidence. The cytotoxic activities of 1-11 were evaluated against selected human cancer cell lines. Compound 4 showed significant selective cytotoxicity against multidrug-resistant cancer cells (KB-C2). The cytotoxicities of compounds 1, 3, 5, 8, and 11 against KB-C2 cells were enhanced in the presence of nontoxic concentrations of colchicine.
新疆阿魏（Ferula varia）根甲醇提取物的乙酸乙酯可溶部分得到了6个新的倍半萜内酯（1-6）和5个已知倍半萜（7-11）。它们的结构通过光谱证据得以确定。评估了1-11对选定人类癌细胞系的细胞毒活性。化合物4对多药耐药癌细胞（KB-C2）显示出显著的选择性细胞毒性。在无毒浓度秋水仙碱存在的情况下，化合物1、3、5、8和11对KB-C2细胞的细胞毒性增强。
