关于单价阳离子激活钙ATP酶的机制
On the mechanism of activation of CaATPase by a single univalent cation.
作者信息
Szász I
出版信息
Acta Biochim Biophys Acad Sci Hung. 1975;10(1-2):25-30.
It has been demonstrated with ox-brain microsome membranes that the mechanism of CaATPase activation by a single univalent cation is different in case of Na+-ont he one hand-and K+ and its congeners-on the other. Whereas Na+ increases the amount of 32-P protein (phosphorylated intermediate), K+ causes only an insignificant increase or decrease compared to the Ca-2+-containing sample. Our findings support the assumption that the altered activity of the Na-K-ATPase (modified by the presence of Ca-2+) is responsible for the univalent cation activation of the CaATPase.
用牛脑微粒体膜已证明，单价阳离子对CaATP酶的激活机制在Na⁺（一方面）与K⁺及其同系物（另一方面）的情况下是不同的。与含Ca²⁺的样品相比，Na⁺增加了³²-P蛋白（磷酸化中间体）的量，而K⁺仅引起微不足道的增加或减少。我们的研究结果支持这样的假设，即Na-K-ATP酶活性的改变（由Ca²⁺的存在所改变）是CaATP酶单价阳离子激活的原因。
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