van der Most Robbert G, Murali-Krishna Kaja, Ahmed Rafi
Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Int Immunol. 2003 Jan;15(1):119-25. doi: 10.1093/intimm/dxg009.
Dengue virus infection in the central nervous system (CNS) of immunized mice results in a strong influx of CD8 T cells into the brain. Whereas the kinetics of the splenic antiviral response are conventional, i.e. expansion followed by a rapid drop in the frequency of specific CD8 T cells, dengue virus-specific CD8 T cells are retained in the CNS at a high frequency. These CD8 T cells display a partially activated phenotype (CD69(high), Ly-6A/E(high), CD62L(low)), characteristic for effector-memory T cells. CD43 expression, visualized by staining with the 1B11 mAb, decreased in time, suggesting that these persisting CD8 T cells differentiated into memory cells. These data add to the growing evidence implicating the CNS as a non-lymphoid tissue capable of supporting prolonged T cell survival/maintenance.
免疫小鼠中枢神经系统(CNS)中的登革病毒感染导致CD8 T细胞大量涌入大脑。虽然脾脏抗病毒反应的动力学是常规的,即先扩增,然后特异性CD8 T细胞频率迅速下降,但登革病毒特异性CD8 T细胞在中枢神经系统中以高频率保留。这些CD8 T细胞表现出部分活化的表型(CD69高、Ly-6A/E高、CD62L低),这是效应记忆T细胞的特征。用1B11单克隆抗体染色可见的CD43表达随时间下降,表明这些持续存在的CD8 T细胞分化为记忆细胞。这些数据进一步证明了中枢神经系统作为一种能够支持T细胞长期存活/维持的非淋巴组织的证据越来越多。