原发性人类免疫缺陷病毒1型对进入抑制剂的基线敏感性。

Baseline susceptibility of primary human immunodeficiency virus type 1 to entry inhibitors.

作者信息

Labrosse Béatrice, Labernardière Jean-Louis, Dam Elisabeth, Trouplin Virginie, Skrabal Katharina, Clavel François, Mammano Fabrizio

机构信息

INSERM U-552, Recherche Antivirale, Hôpital Bichat-Claude Bernard, Paris, France.

出版信息

J Virol. 2003 Jan;77(2):1610-3. doi: 10.1128/jvi.77.2.1610-1613.2003.

DOI:10.1128/jvi.77.2.1610-1613.2003

PMID:12502877

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC140831/

Abstract

Human immunodeficiency virus type 1 plasma viruses from 29 entry inhibitor-naive patients were characterized for their susceptibilities to T-20, AMD3100, and RANTES. A strikingly wide range of susceptibilities to T-20 was observed that was influenced by coreceptor usage but not by the susceptibilities of the viruses to inhibitors that target the chemokine receptors or by polymorphisms in the gp41 N helix.

摘要

对29名未接受过进入抑制剂治疗的患者的1型人类免疫缺陷病毒血浆病毒进行了表征，以确定它们对T-20、AMD3100和RANTES的敏感性。观察到对T-20的敏感性范围差异很大，这受到共受体使用情况的影响，但不受病毒对靶向趋化因子受体的抑制剂的敏感性或gp41 N螺旋多态性的影响。