Champness J N, Bloomer A C, Bricogne G, Butler P G, Klug A
Nature. 1976;259(5538):20-4. doi: 10.1038/259020a0.
An electron density map of the TMV disk at 5A resolution has been obtained using isomorphous replacement and non-crystallographic symmetry. The polypeptide chain can be traced with little ambiguity. The axial contacts between protein subunits are unlike those in the virus, the disk being a more open structure apparently designed for rapid interaction with the RNA.
利用同晶置换和非晶体学对称性获得了分辨率为5埃的烟草花叶病毒盘状颗粒的电子密度图。多肽链的走向清晰可辨。蛋白质亚基之间的轴向接触与病毒中的不同，盘状颗粒是一种更开放的结构，显然是为了与RNA快速相互作用而设计的。
