Ordian N E, Pivina S G, Rakitskaia V V
I. P. Pavlov Institute of Physiology of the Russian Acad. Sci., St. Petersburg, 199034, Nab. Makarova, 6.
Ross Fiziol Zh Im I M Sechenova. 2002 Aug;88(8):1003-9.
Administration of hydrocortisone or 6-hydroxydopamine (6-ONDA) to little rats from the 1st to the 5th day of life affected functional activity of the hypophyseal-adrenal system (HAS) of immature rats. In the morning hours, the rats developed a decrease in the basal and stressor levels of corticosterone in the blood, whereas administration of the 6-ONDA did not change the functional activity of the HAS in the morning. The data obtained suggest that disorders in the HAS regulation by the feedback mechanism resulting from neonatal administration of hydrocortisone may be associated with a drop in the noradrenaline level in the hypothalamus.
在幼鼠出生后第1天至第5天给予氢化可的松或6-羟基多巴胺（6-OHDA）会影响未成熟大鼠垂体-肾上腺系统（HAS）的功能活性。在上午时段，大鼠血液中皮质酮的基础水平和应激水平均下降，而给予6-OHDA在上午并未改变HAS的功能活性。所获数据表明，新生期给予氢化可的松导致反馈机制对HAS调节出现紊乱，可能与下丘脑去甲肾上腺素水平下降有关。
