唐氏综合征患儿的甲状腺功能障碍及高促甲状腺激素水平

Thyroid dysfunction and high thyroid stimulating hormone levels in children with Down's syndrome.

作者信息

Gruñeiro de Papendieck Laura, Chiesa A, Bastida M G, Alonso G, Finkielstain G, Heinrich J J

机构信息

Division Endocrinologia, Hospital de Niños R. Gutierrez, CEDIE, Buenos Aires, Argentina.

出版信息

J Pediatr Endocrinol Metab. 2002 Nov-Dec;15(9):1543-8. doi: 10.1515/jpem.2002.15.9.1543.

DOI:10.1515/jpem.2002.15.9.1543

PMID:12503863

Abstract

UNLABELLED

In order to delineate the spectrum of thyroid abnormalities in children with Down's syndrome (DS), first visit height data (SDS) and serum TSH, T4 and antiperoxidase antibodies concentrations were retrospectively evaluated in 137 children (71 girls) with DS (0.04-16 years).

RESULTS

Congenital hypothyroidism was detected in 2.9% of patients. Thyroid disease occurred in 9%: four hyperthyroidism and eight hypothyroidism. Overt thyroid disease was always related to thyroid autoimmunity. The remaining 121 patients had normal T4 levels but increased mean TSH compared with controls (4.7 +/- 2.8 vs 2.3 +/- 1.3 mU/l). According to TSH levels, they were divided into two groups: G1 (n = 68) with normal TSH (<5 mU/l), and G2 (n = 53) with high TSH (> 5 mU/l). T4 levels were significantly lower in G2 (p < 0.01 vs G1 and controls). Height SDS was not different.

CONCLUSIONS

Thyroid disorders are frequent in children with DS. Subtle thyroid abnormalities found in patients with DS with no evidence of clinical dysfunction need further investigation to demonstrate whether there is a need for therapeutic intervention.

摘要

未标注

为了描绘唐氏综合征（DS）患儿甲状腺异常的范围，对137例DS患儿（71例女孩，年龄0.04 - 16岁）首次就诊时的身高数据（标准差分值）以及血清促甲状腺激素（TSH）、甲状腺素（T4）和抗过氧化物酶抗体浓度进行了回顾性评估。

结果

2.9%的患者被检测出先天性甲状腺功能减退。甲状腺疾病发生率为9%：4例甲状腺功能亢进和8例甲状腺功能减退。明显的甲状腺疾病总是与甲状腺自身免疫有关。其余121例患者T4水平正常，但与对照组相比，平均TSH升高（4.7±2.8 vs 2.3±1.3 mU/L）。根据TSH水平，他们被分为两组：G1组（n = 68）TSH正常（<5 mU/L），G2组（n = 53）TSH升高（>5 mU/L）。G2组T4水平显著降低（与G1组和对照组相比，p < 0.01）。身高标准差分值无差异。