科威特唐氏综合征患者的甲状腺功能。

Thyroid function in Kuwaiti subjects with Down's syndrome.

作者信息

Ali Fawzi E, Bayoumy Hossam A, Mohammad Abdul Salam R, Al-Busairi Waleed A, Al-Othman Abdul Naser A

机构信息

Medical Rehabilitation Centre, Ministry of Social Affairs, Surra, Kuwait.

出版信息

Med Princ Pract. 2002 Oct-Dec;11(4):206-9. doi: 10.1159/000065807.

DOI:10.1159/000065807

PMID:12424416

Abstract

OBJECTIVE

To investigate the thyroid function of individuals with Down's syndrome (DS).

METHODS

Thyroid function and antithyroid antibodies were measured in 58 Kuwaitis with DS who resided at a residential facility or attended rehabilitation centers.

RESULTS

Twenty-six subjects (45%) were euthyroid and 32 (55%) had thyroid dysfunction. One patient had previously been diagnosed with thyroid failure whereas the other 31 patients had newly discovered disease: 9 patients had primary hypothyroidism (T(4) 9.95 +/- 1.1 pmol/l and TSH 15.15 +/- 11.93 mU/l), 19 subclinical hypothyroidism (TSH 6.47 +/- 2.57 mU/l), 1 secondary hypothyroidism, 1 hyperthyroidism, and the remaining 1 subclinical hyperthyroidism. Antithyroid antibodies were found in 52% of the total subjects and in 59% of those with thyroid dysfunction.

CONCLUSIONS

Thyroid dysfunction is common in Kuwaiti subjects with DS and is presumably the consequence of autoimmune thyroid disease. Periodic thyroid function testing is recommended in individuals with DS, which is best done through a national program.

摘要

目的

研究唐氏综合征（DS）患者的甲状腺功能。

方法

对58名居住在寄宿机构或参加康复中心的科威特DS患者进行甲状腺功能和抗甲状腺抗体检测。

结果

26名受试者（45%）甲状腺功能正常，32名（55%）有甲状腺功能障碍。1例患者先前被诊断为甲状腺功能减退，其他31例患者为新发现的疾病：9例为原发性甲状腺功能减退（T4 9.95±1.1 pmol/l，TSH 15.15±11.93 mU/l），19例为亚临床甲状腺功能减退（TSH 6.47±2.57 mU/l），1例为继发性甲状腺功能减退，1例为甲状腺功能亢进，其余1例为亚临床甲状腺功能亢进。在52%的受试者和59%的甲状腺功能障碍患者中发现了抗甲状腺抗体。