Seddik Salwa S, Wanas Soheir, Helmy Madiha H, Hashem Mohamed
Egyptian Organization for Biological Products & Vaccines (VACSERA), 51 Wezaret El Zeraa St., Agouza, Giza, Egypt.
J Nat Toxins. 2002 Dec;11(4):329-35.
This study was performed to assess the ability of polyvalent snake venom anti-serum, produced by the Egyptian Organization for Biological Products & Vaccines (VACSERA), to neutralize several toxic activities of snake venoms, not only of those included in the antivenom mixture, but also some additional venoms of snakes from Egyptian, African, and Middle Eastern habitats. In general, the results revealed that polyvalent snake venom anti-serum from VACSERA is highly effective in neutralizing Egyptian snake venoms, especially Naja haje, Naja nigricolles, Naja pallida, Cerastes cerastes, Cerastes cerastes cerastes, Cerastes vipera, Pseudocerastes persicus fieldi, and Walterinnisia egyptia. The antivenom was also effective against Naja haje, Walterinnisia egyptia, and Bites aritans from Saudi Arabia. High activity was obtained against venoms from Naja haje, Naja nigricolles, and Naja pallida of Sudan, as well as the African Naja melanoleuca, Naja mossambica, Naja naja oxiana, Bites gabonica, and Vipera lebetina. Only moderate effectiveness was obtained with Echis coloratus and Echis carinatus, and the polyvalent antiserum was ineffective against the venom of Naja nivea.
本研究旨在评估埃及生物制品与疫苗组织（VACSERA）生产的多价蛇毒抗血清中和蛇毒多种毒性活性的能力，这些蛇毒不仅包括抗蛇毒血清混合物中的蛇毒，还包括来自埃及、非洲和中东栖息地的一些其他蛇类的毒液。总体而言，结果表明，VACSERA的多价蛇毒抗血清在中和埃及蛇毒方面非常有效，尤其是埃及眼镜蛇、黑颈眼镜蛇、淡色眼镜蛇、角蝰、锯鳞蝰、膨蝰、波斯沙蝰指名亚种和埃及矛头蝮。该抗蛇毒血清对来自沙特阿拉伯的埃及眼镜蛇、埃及矛头蝮和鼓腹咝蝰也有效。对来自苏丹的埃及眼镜蛇、黑颈眼镜蛇和淡色眼镜蛇的毒液，以及非洲的黑曼巴蛇、莫桑比克射毒眼镜蛇、中亚眼镜蛇、加蓬咝蝰和草原蝰的毒液，均表现出高活性。对锯鳞蝰和角蝰的毒液仅表现出中等效力，而该多价抗血清对雪白眼镜蛇的毒液无效。
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