胚胎冷冻保存对每次体外受精治疗累积持续妊娠率的附加值：冷冻保存是否值得付出努力？
The added value of embryo cryopreservation to cumulative ongoing pregnancy rates per IVF treatment: is cryopreservation worth the effort?
作者信息
de Jong D, Eijkemans M J C, Beckers N G M, Pruijsten R V, Fauser B C J M, Macklon N S
机构信息
Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus Medical Centre, Rotterdam, The Netherlands.
出版信息
J Assist Reprod Genet. 2002 Dec;19(12):561-8. doi: 10.1023/a:1021211115337.
PURPOSE
To calculate the added benefit of a cryopreservation program to the cumulative ongoing pregnancy rate over a maximum of three cycles of IVF.
METHODS
A total of 1251 couples beginning their first IVF treatment between January 1995 and December 1999 were evaluated. Ongoing pregnancies from fresh and subsequent cryopreserved embryo transfer cycles were analyzed. Pregnancies arising from the cryopreservation cycle were considered to augment the cumulative pregnancy rate when no ongoing pregnancy arose from the fresh embryo transfer cycle.
RESULTS
The ongoing pregnancy rate per cryopreserved embryo transfer was 11.7%. The cumulative ongoing pregnancy rate following three successive started fresh IVF cycles was 42.5%. When pregnancies arising from the transfer of thawed cryopreserved embryos were included, the cumulative ongoing pregnancy rate increased to 43.8%, rising to 44.8% when extrapolated data from as yet unthawed embryos was included.
CONCLUSIONS
When analyzed in these terms, the supplementary benefit of cryopreserving supranumerical embryos appears limited.
目的
计算冷冻保存方案对最多三个体外受精周期累积持续妊娠率的额外益处。
方法
对1995年1月至1999年12月期间开始首次体外受精治疗的1251对夫妇进行评估。分析新鲜胚胎移植周期及随后冷冻胚胎移植周期的持续妊娠情况。当新鲜胚胎移植周期未出现持续妊娠时，冷冻保存周期产生的妊娠被视为增加累积妊娠率。
结果
每次冷冻胚胎移植的持续妊娠率为11.7%。连续三个开始的新鲜体外受精周期后的累积持续妊娠率为42.5%。当纳入解冻冷冻胚胎移植产生的妊娠时，累积持续妊娠率增至43.8%，若纳入来自尚未解冻胚胎的推断数据，则升至44.8%。
结论
从这些方面分析，冷冻保存多余胚胎的额外益处似乎有限。
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