对血管内皮大麻素受体的探索。

The quest for a vascular endothelial cannabinoid receptor.

作者信息

Kunos George, Bátkai Sándor, Offertáler László, Mo Fanny, Liu Jie, Karcher Jan, Harvey-White Judith

机构信息

National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 12420 Parklawn Drive MSC-8115, Bethesda, MD 20892-8115, USA.

出版信息

Chem Phys Lipids. 2002 Dec 31;121(1-2):45-56. doi: 10.1016/s0009-3084(02)00145-7.

DOI:10.1016/s0009-3084(02)00145-7

PMID:12505689

Abstract

This review examines pharmacological and biochemical evidence that suggests the existence of an as yet undefined endothelial receptor that mediates endocannabinoid-induced vasodilation. The signaling mechanisms triggered through this receptor and its potential physiological role are also discussed. Since vasodilation is often associated with hypotension, mechanisms involved in the hypotensive actions of cannabinoids, including the endocannabinoids anandamide and 2-arachidonoylglycerol, are also briefly reviewed.

摘要

本综述考察了药理学和生物化学证据，这些证据表明存在一种尚未明确的内皮受体，该受体介导内源性大麻素诱导的血管舒张。还讨论了通过该受体触发的信号传导机制及其潜在的生理作用。由于血管舒张通常与低血压相关，因此还简要综述了大麻素（包括内源性大麻素花生四烯乙醇胺和2-花生四烯酸甘油）的降压作用所涉及的机制。