Hillard C J
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
J Pharmacol Exp Ther. 2000 Jul;294(1):27-32.
Marijuana is used by humans for its psychoactive and medicinal effects. The active constituents of marijuana, the cannabinoids, exert effects via a G protein-coupled receptor, CB(1). Two arachidonic acid analogs, N-arachidonylethanolamine and 2-arachidonylglycerol are hypothesized to function as endogenous ligands of the CB(1) receptor. The cannabinoids exert significant vascular effects in humans and laboratory animals. In particular, the cannabinoids produce vasodilation and hypotension. The possible mechanisms for these effects are inhibition of transmitter release from sympathetic nerve terminals, direct effects on vascular smooth muscle cells, and effects on endothelial cell function. The data regarding these effects of the cannabinoids and possible sources of endocannabinoid ligands in the vasculature are the subjects of this review.
人类使用大麻是因其具有精神活性和药用效果。大麻的活性成分大麻素，通过G蛋白偶联受体CB(1)发挥作用。两种花生四烯酸类似物，N-花生四烯酰乙醇胺和2-花生四烯酰甘油，被推测作为CB(1)受体的内源性配体发挥作用。大麻素在人类和实验动物中产生显著的血管效应。特别是，大麻素会引起血管舒张和低血压。这些效应的可能机制是抑制交感神经末梢释放递质、对血管平滑肌细胞的直接作用以及对内皮细胞功能的影响。关于大麻素这些效应以及血管中内源性大麻素配体可能来源的数据是本综述的主题。
