载脂蛋白E基因多态性与临床诊断的脂肪性肝病的关系
[Relation of apolipoprotein E polymorphism to clinically diagnosed fatty liver disease].
作者信息
Lee Dong-Min, Lee Seung-Ok, Mun Byoung-Sik, Ahn Heok-Soo, Park Hye-Young, Lee Hye-Soo, Kim Dae-Ghon
机构信息
Department of Internal Medicine, Chonbuk National University College of Medicine, Chonju, Korea.
出版信息
Taehan Kan Hakhoe Chi. 2002 Dec;8(4):355-62.
BACKGROUND/AIMS: Apolipoprotein E (Apo E) is important in plasma lipid metabolism and is a component of several plasma lipoprotein-lipid particles. Three major Apo E isoforms are encoded by three common allelic forms, epsilon2, epsilon3, and epsilon4 at the APO E locus. The goal of this study was to examine the association between polymorphisms in the apolipoprotein E gene (APOE) and fatty liver disease.
METHODS
We examined the distribution of APOE alleles from 116 fatty liver patients and 50 controls in Korea.
RESULTS
The frequencies of APOE alleles in fatty liver patients were 6.5% in epsilon2, 85.7% in epsilon3 and 7.8% in epsilon4. The corresponding frequencies in control subjects were 4.0% in epsilon2, 91.0% in epsilon3 and 5.0% in epsilon4. There were no significant differences in the distribution of APOE genotypes between fatty liver patients and controls. APOE epsilon2 and epsilon4 allele frequencies in fatty liver patients were more than those in controls. However, there was no significant differences in APOE epsilon2 and epsilon4 allele frequencies.
CONCLUSIONS
These results suggest that APOE alleles seem not to be directly associated with the pathogenesis of fatty liver disease.
背景/目的：载脂蛋白E（Apo E）在血浆脂质代谢中起重要作用，是几种血浆脂蛋白-脂质颗粒的组成成分。APO E基因座上的三种常见等位基因形式ε2、ε3和ε4编码三种主要的Apo E异构体。本研究的目的是检测载脂蛋白E基因（APOE）多态性与脂肪性肝病之间的关联。
方法
我们检测了韩国116例脂肪性肝病患者和50例对照者的APOE等位基因分布情况。
结果
脂肪性肝病患者中APOE等位基因的频率分别为：ε2为6.5%，ε3为85.7%，ε4为7.8%。对照者中相应的频率分别为：ε2为4.0%，ε3为91.0%，ε4为5.0%。脂肪性肝病患者和对照者之间APOE基因型的分布没有显著差异。脂肪性肝病患者中APOE ε2和ε4等位基因频率高于对照者。然而，APOE ε2和ε4等位基因频率没有显著差异。
结论
这些结果表明，APOE等位基因似乎与脂肪性肝病的发病机制没有直接关联。
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