Watts Patrick O, Neveu Magella M, Holder Graham E, Sloper John J
Moorfields Eye Hospital, London, United Kingdom.
J AAPOS. 2002 Dec;6(6):389-92. doi: 10.1067/mps.2002.129046.
To assess electrophysiological recovery in successfully treated strabismic amblyopes.
Pattern reversal visual evoked potentials were recorded from 11 successfully treated strabismic amblyopes 7 to 11 years of age and 10 age-matched normal children using 12.5' and 50' checks.
Nine amblyopic eyes had recovered to a Snellen acuity of 6/6 or better, and the remaining 2 were 6/9 after patching. Comparison between the amblyopic and the fellow eyes showed significantly lower P100 amplitude for the amblyopic eyes with small checks (difference -16.7%; P <.02) and significantly longer latency with larger checks difference (+5.0%; P <.02). The P100 latencies to stimulation of both the amblyopic and fellow eyes by 12.5' checks were markedly longer than in normal subjects (amblyopic eye, +11.7%, P <.0001; fellow eye, +7.7% P <.002).
Successfully treated amblyopic eyes showed significantly longer latency than did normal eyes with small check stimulation. However, the nonamblyopic fellow eyes also showed significantly longer latency than did normal eyes, suggesting altered central processing.
评估成功治疗的斜视性弱视患者的电生理恢复情况。
使用12.5'和50'的方格刺激，对11名年龄在7至11岁、成功治疗的斜视性弱视患者以及10名年龄匹配的正常儿童进行图形翻转视觉诱发电位记录。
9只弱视眼经遮盖治疗后视力恢复至6/6或更好，其余2只恢复至6/9。弱视眼与对侧眼相比，小方格刺激时弱视眼的P100波幅显著降低（差异为-16.7%；P<.02），大方格刺激时潜伏期显著延长（差异为+5.0%；P<.02）。12.5'方格刺激时，弱视眼和对侧眼的P100潜伏期均显著长于正常受试者（弱视眼，+11.7%，P<.0001；对侧眼，+7.7%，P<.002）。
成功治疗的弱视眼在小方格刺激时潜伏期显著长于正常眼。然而，非弱视的对侧眼潜伏期也显著长于正常眼，提示中枢处理过程发生改变。
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