一种由5-氨基-1-β-D-呋喃核糖基-4-咪唑甲酰胺合成肌苷的新方法。
A new synthesis of inosine from 5-amino-1-beta-D-ribofuranosyl-4-imidazole-carboxamide.
作者信息
Okutsu M, Yamazaki A
出版信息
Nucleic Acids Res. 1976 Jan;3(1):231-5. doi: 10.1093/nar/3.1.231.
Abstract
Inosine was prepared (15% yield) by treatment of 5-amino-1-beta-D-ribofuranosyl-4-imidazolecarboxamide (AICA-riboside) with chloroform in the presence of sodium methoxide. This ring closure can be reasonably explained by assuming the formation of dichlorocarbene from chloroform and alkali. Carbon tetrachloride or hexachloroethane as a carbene source was more effective for the ring closure of AICA-riboside, giving inosine in 48% and 51% yields respectively.
摘要
在甲醇钠存在下，用氯仿处理5-氨基-1-β-D-呋喃核糖基-4-咪唑甲酰胺（AICA-核苷）制备了肌苷（产率15%）。这种环化反应可以通过假定氯仿与碱形成二氯卡宾来合理解释。以四氯化碳或六氯乙烷作为卡宾源对AICA-核苷的环化反应更有效，分别以48%和51%的产率得到肌苷。
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本文引用的文献
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Isolation of 5-amino-4-imidazolecarboxamide riboside.5-氨基-4-咪唑甲酰胺核糖苷的分离
J Biol Chem. 1956 Mar;219(1):411-22.
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