Holzmann H, Hoffmann G, Schwarz P, Morsches B, Oertel G W, Fränz J
Arch Dermatol Forsch. 1975;252(2):151-9.
In psoriasis changes of the DHEA metabolism could be demonstrated. These genetically determined basic alterations may represent an important factor for the manifestation of psoriasis. They consist of a decreased penetration of DHEA through the cell membrane and an increased reduction of DHEA to ADIOL, leading to a reduced DHEA/ADIOL ratio. In the present investigations the question was whether the assay of these parameters may aid in the detection of latent psoriasis. For this purpose 31 members form 6 unselected families of psoriatics (8 manifested psoriatics, 18 potential psoriatics, 5 clinically and anamnestically healthy family members by marriage) as well as 6 further controls were examined. It could be shown that those changes in the DHEA metabolism, which are evident in manifested psoriatics also occur at least in part of potential psoriatics. However, both parameters investigated do not always behave the same way. Hence, from the present data a satisfactory diagnosis of latent psoriasis does not seem possible. Still, the estimation of the above parameters may aid in the attempts to define latent psoriasis. Further investigations of such families are warranted for final elucidation of this problem.
在银屑病中，可以证实存在脱氢表雄酮（DHEA）代谢的变化。这些由基因决定的基本改变可能是银屑病发病的一个重要因素。它们包括DHEA透过细胞膜的渗透率降低以及DHEA还原为雄烯二醇（ADIOL）的过程增强，导致DHEA/ADIOL比值降低。在本研究中，问题在于对这些参数的检测是否有助于隐匿性银屑病的诊断。为此，对来自6个未经过挑选的银屑病患者家庭的31名成员（8名已患银屑病者、18名潜在银屑病患者、5名临床及既往史均健康的已婚家庭成员）以及另外6名对照者进行了检查。结果表明，那些在已患银屑病者中明显的DHEA代谢变化至少在部分潜在银屑病患者中也会出现。然而，所研究的这两个参数并不总是表现一致。因此，根据目前的数据，似乎无法对隐匿性银屑病做出令人满意的诊断。尽管如此，对上述参数的评估可能有助于尝试界定隐匿性银屑病。有必要对这类家庭进行进一步研究以最终阐明这个问题。
