Holzmann H, Benes P, Morsches B, Matthaei D, Stöhr L
Dtsch Med Wochenschr. 1981 Sep 25;106(39):1245-7. doi: 10.1055/s-2008-1070490.
Free dehydroepiandrosterone (DHEA), DHEA sulphate, testosterone, LH and FSH were measured in plasma from 67 patients with renal disease before and after haemodialysis or haemofiltration. Plasma concentration of the steroid hormones was lower in patients with renal failure than in normal controls, while that of the gonadotrophic hormones was elevated. After haemodialysis or haemofiltration DHEA sulphate level in plasma decreased, free DHEA increased significantly reaching almost the initial value of the control group. There was no change in concentration of the other steroid and gonadotrophic hormones. The likely mechanism is that haemodialysis removes DHEA deficiency in patients with psoriasis which is assumed to be an aetiopathogenetic factor in the disease.
在67例肾病患者进行血液透析或血液滤过前后，测定其血浆中的游离脱氢表雄酮（DHEA）、硫酸脱氢表雄酮、睾酮、促黄体生成素（LH）和促卵泡生成素（FSH）。肾衰竭患者血浆中甾体激素的浓度低于正常对照组，而促性腺激素的浓度则升高。血液透析或血液滤过后，血浆中硫酸脱氢表雄酮水平下降，游离DHEA显著增加，几乎达到对照组的初始值。其他甾体激素和促性腺激素的浓度没有变化。可能的机制是血液透析清除了银屑病患者体内的DHEA缺乏，而DHEA缺乏被认为是该疾病的一个发病机制因素。
