Gazzaniga A B, James J M, Shobe J B, Oppenheim E B
Arch Surg. 1975 Apr;110(4):429-32. doi: 10.1001/archsurg.1975.01360100071012.
Peritoneal adhesions were created in rats by brisk scrubbing of the terminal part of the ileum. Adhesions were graded by total number and the presence of small bowel obstruction. Adhesion prophylaxis was evaluated using dexamethasone, methylprednisolone sodium succinate, promethazine hydrochloride, and human fibrinolysin (Thrombolysin) in various combinations, doses, and routes of administration. Methylprednisolone and dexamethasone, depending on the route of administration, modified the total number of adhesions but did not modify their severity when compared to control animals. Promethazine by itself modified peritoneal adhesions in the rat. Used together, methylprednisolone and promethazine also modified adhesions, but were not substantially better than the combination of dexamethasone and promethazine. Methylprednisolone, promethazine, and human fibrinolyzin, when used in combination intraperitoneally, virtually eliminated adhesion formation.
通过快速擦洗大鼠回肠末端来形成腹膜粘连。根据粘连总数和小肠梗阻情况对粘连进行分级。使用地塞米松、甲泼尼龙琥珀酸钠、盐酸异丙嗪和人纤维蛋白溶酶（溶栓酶）以各种组合、剂量和给药途径评估粘连预防效果。与对照动物相比，甲泼尼龙和地塞米松根据给药途径改变了粘连总数，但未改变其严重程度。异丙嗪本身可改变大鼠的腹膜粘连。甲泼尼龙和异丙嗪联合使用时也可改变粘连情况，但并不比地塞米松和异丙嗪的组合显著更好。甲泼尼龙、异丙嗪和人纤维蛋白溶酶腹腔内联合使用时，几乎可消除粘连形成。
