Sahin Mustafa, Cakir Murat, Avsar Fatih Mehmet, Tekin Ahmet, Kucukkartallar Tevfik, Akoz Mehmet
Department of General Surgery, Selcuk University Meram Medical Faculty, Konya, Turkey.
Inflammation. 2007 Dec;30(6):244-9. doi: 10.1007/s10753-007-9043-1. Epub 2007 Aug 10.
The purpose of this study was to compare the effects of anti-adhesion materials in postoperative adhesions.
Rats were assigned to five groups: Group 1: Control. Group 2: chitin layers were used. Group 3: Na-hyaluronate / carboxymethylcellulose layers were used. Group 4: Na-hyaluronate gel was poured into the abdomen. Group 5: methylprednisolone was injected. The adhesion frequency and grade were scored according to Granat. Blood was taken for Hb, AST, BUN and albumin levels determination.
The adhesion frequencies (right and left) and grades were as follow in Groups; I: 82%, 91%, 2.63 +/- 1.22; II: 8.3%, 25%, 0.58 +/- 0.66; III: 17%, 33%, 1.08 +/- 1.08; IV: 50%, 58%, 1.41 +/- 1.44; V: 50%, 42%, 1.41 +/- 1.50. The adhesion phase in all study groups was found significantly low compared to control group, p < 0.05. No difference was observed among serologic and hematological parameters in all groups.
All the materials used significantly lowered the adhesion frequency and grade.
本研究旨在比较抗粘连材料对术后粘连的影响。
将大鼠分为五组：第1组：对照组。第2组：使用几丁质层。第3组：使用透明质酸钠/羧甲基纤维素层。第4组：向腹腔内注入透明质酸钠凝胶。第5组：注射甲基强的松龙。根据格拉纳特法对粘连频率和等级进行评分。采集血液测定血红蛋白、谷草转氨酶、尿素氮和白蛋白水平。
各组的粘连频率（左右）和等级如下：第I组：82%，91%，2.63±1.22；第II组：8.3%，25%，0.58±0.66；第III组：17%，33%，1.08±1.08；第IV组：50%，58%，1.41±1.44；第V组：50%，42%，1.41±1.50。与对照组相比，所有研究组的粘连期均显著降低，p<0.05。所有组的血清学和血液学参数均未观察到差异。
所有使用的材料均显著降低了粘连频率和等级。
