Yang Guo-Sheng, Lu Ren-Kang, Chen Zhao-Dian
Department of Urology, First Affiliated Hospital, Medical School of Zhejiang University, Hangzhou 310003, China.
Asian J Androl. 2002 Dec;4(4):255-8.
To explore the changes of epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) expressions in cryptorchid children and their clinical significance.
The level of serum EGF was measured by radioimmunoassay (RIA) and the expression of EGFR by immunohistochemistry.
(1) The level of serum EGF was significantly lower in cryptorchid children than in normal subjects at age group of 5-9 years (P<0.01) and 10-14 years (P<0.01), (2) The level of EGF was significantly lower in boys with impalpable testis than in those with extracanalicular and intracanalicular testes (P<0.01), (3) The serum EGF level increased significantly 6 months after orchiopexy (P<0.05), (4) The EGFR expression in testicular Leydig's cells was lower in 2 approximately 4 year-old boys than in those over 5 years (P<0.05) and (5) the EGFR expression was less positive in the impalpable group and the intracanalicular group than that of the extracanalicular group (P<0.01).
The EGF and EGFR expressions may correlate with the age and the position of testes; orchiopexy improves the EGF and EGFR expressions in cryptorchid boys.
探讨隐睾患儿表皮生长因子（EGF）及表皮生长因子受体（EGFR）表达的变化及其临床意义。
采用放射免疫分析法（RIA）检测血清EGF水平，免疫组织化学法检测EGFR表达。
（1）5 - 9岁及10 - 14岁隐睾患儿血清EGF水平显著低于正常受试者（P<0.01）；（2）不可触及睾丸的男孩EGF水平显著低于睾丸位于腹股沟管外及腹股沟管内的男孩（P<0.01）；（3）睾丸固定术后6个月血清EGF水平显著升高（P<0.05）；（4）2至4岁左右男孩睾丸间质细胞中EGFR表达低于5岁以上男孩（P<0.05）；（5）不可触及组和腹股沟管内组EGFR表达阳性率低于腹股沟管外组（P<0.01）。
EGF和EGFR表达可能与年龄及睾丸位置有关；睾丸固定术可改善隐睾患儿的EGF和EGFR表达。
