骨髓抑制对粒细胞调理素水平的影响。

Effect of bone marrow suppression on granulocyte opsonin levels.

作者信息

Andersen B R, Debelak-Fehir K M, Epstein R B

出版信息

Proc Soc Exp Biol Med. 1976 Jan;151(1):105-9. doi: 10.3181/00379727-151-39153.

Abstract

Levels of serum opsonin for neutrophilic granulocytes were measured in dogs made neutropenic by cyclophosphamide administration. Heat-labile opsonin became elevated within 24 hr following cyclophosphamide (P less than 0.005) and remained elevated over the 4-5 day period of observation (P less than 0.005). In contrast, heat stable opsonin was not significantly effected. Bone marrow suppression by X-ray and busulfan also caused serum opsonin levels to increase. Changes in the levels of IgG, C3, and total hemolytic complement during the course of bone marrow suppression did not correlate with the granulocyte opsonin levels. These findings suggest that serum granulocyte opsonin levels respond to bone marrow suppression and may provide an improved environment for the function of transfused granulocytes.

摘要

对通过给予环磷酰胺造成中性粒细胞减少的犬，检测其血清嗜中性粒细胞调理素水平。热不稳定调理素在给予环磷酰胺后24小时内升高（P<0.005），并在4 - 5天的观察期内持续升高（P<0.005）。相比之下，热稳定调理素未受到显著影响。X射线和白消安所致的骨髓抑制也导致血清调理素水平升高。骨髓抑制过程中IgG、C3和总溶血补体水平的变化与粒细胞调理素水平不相关。这些发现提示血清粒细胞调理素水平对骨髓抑制有反应，并且可能为输注的粒细胞功能提供更好的环境。