van Velzen-Blad H, Dijkstra Y J, Schurink G A, Verbrugh H A, Verhoef J, Zegers B J, Ballieux R E
Ann Thorac Surg. 1985 Mar;39(3):207-11. doi: 10.1016/s0003-4975(10)62578-7.
In patients undergoing open-heart surgical procedures, the serum levels of immunoglobulins and complement were determined as well as the functional capacity of these defense proteins as opsonins to facilitate phagocytosis by polymorphonuclear leukocytes. A considerable decrease in serum levels of the proteins studied was found after cardiopulmonary bypass (CPB). As a result, the opsonic capacity of post-CPB plasma was diminished. After correction for hemodilution, however, no difference between pre- and post-CPB plasma, as measured by the activity of thermolabile (e.g., complement C3) and thermostabile (e.g., immunoglobulin IgG) opsonins, could be demonstrated. It is concluded that CPB causes a quantitative but no functional decrease in levels of IgG and C3.
在接受心脏直视手术的患者中，测定了免疫球蛋白和补体的血清水平以及这些防御蛋白作为调理素促进多形核白细胞吞噬作用的功能能力。体外循环（CPB）后，所研究蛋白质的血清水平显著下降。结果，CPB后血浆的调理能力降低。然而，在纠正血液稀释后，通过热不稳定（如补体C3）和热稳定（如免疫球蛋白IgG）调理素的活性测定，CPB前后血浆之间没有差异。得出的结论是，CPB导致IgG和C3水平在数量上下降，但功能上无下降。
